

Suitable for individuals experiencing general fatigue who need comprehensive liver support and enhanced physical recovery. Hepalyse Hi Plus combines Liver Hydrolysate, Taurine, L-Carnitine, B vitamins, Royal Jelly, and six traditional herbal extracts to help support normal liver function, promote energy metabolism, improve physical vitality, and relieve fatigue.
Country of Origin: Japan
Brand: Hepalyse (ヘパリーゼ)
Manufacturer: Zeria Pharmaceutical Co., Ltd.
Packaging: 50 mL bottle; Box of 10 × 50 mL bottles
Suggested Retail Price (Japan):
Main benefits:
– Supports normal liver function
– Helps relieve general physical fatigue and weakness
– Provides nutritional support during illness, recovery, or physical exhaustion
– Supports energy metabolism with Liver Hydrolysate, Taurine, L-Carnitine, and B vitamins
– Contains Royal Jelly and traditional herbal extracts to provide additional nutritional support and help maintain physical vitality.
Directions for use:
– Adults aged 15 years and over
– Take 1 bottle (50 mL) once daily
– Do not use for children under 15 years of age
The liver is one of the body’s most important metabolic organs, performing hundreds of essential functions including nutrient metabolism, protein synthesis, and the processing of naturally occurring substances within the body. Modern lifestyles—such as irregular eating habits, physical fatigue, prolonged stress, and frequent alcohol consumption—can increase the body’s nutritional demands and place additional metabolic demands on the liver.
Hepalyse Hi Plus is a premium Class 2 OTC medicine developed by Zeria Pharmaceutical (Japan). It features a comprehensive formulation containing Liver Hydrolysate, Taurine, L-Carnitine, Royal Jelly, B vitamins, and six traditional botanical ingredients to provide nutritional support, help maintain normal liver function, support energy metabolism, and relieve general fatigue and physical weakness.
Liver Hydrolysate
Liver Hydrolysate provides peptides and amino acids that help supplement essential nutrients and support normal liver function during periods of fatigue and recovery.
Taurine
Taurine supports normal physiological function and energy metabolism, helping maintain physical performance during periods of fatigue.
L-Carnitine
L-Carnitine plays an important role in fatty acid metabolism by transporting fatty acids into the mitochondria, where they are converted into usable energy.
Royal Jelly and B Vitamins
Royal Jelly, together with Vitamins B2, B6, and Nicotinamide, helps provide nutritional support and contributes to normal cellular energy production.
Traditional Botanical Ingredients
Schisandra, Lycium (Goji Berry), Dodder Seed, Hawthorn, and Epimedium have long been used in traditional herbal practice and are included to provide additional nutritional support and help maintain overall vitality.
Hepalyse Hi Plus may be suitable for adults who:
Use only as directed. Hepalyse Hi Plus is not intended to diagnose, treat, cure, or prevent any disease.
| Feature | Hepalyse Drink II | Hepalyse Hi Plus |
|---|---|---|
| OTC Classification | Class 3 OTC | Class 2 OTC |
| Liver Hydrolysate | 200 mg | 200 mg |
| Taurine | 1,000 mg | 1,000 mg |
| Royal Jelly | — | ✓ 100 mg |
| L-Carnitine | — | ✓ 100 mg |
| Chondroitin Sulfate Sodium | 120 mg | 200 mg |
| Vitamin B2 | 5 mg | 10 mg |
| Nicotinamide | 20 mg | 30 mg |
| Botanical Ingredients | 3 | 6 |
| Formula | Daily liver support | More comprehensive nutritional support |
| Suitable For | Daily nutritional support and general fatigue | Individuals seeking a more comprehensive formula with additional nutrients and botanical ingredients |
Choose Hepalyse Drink II if you:
Choose Hepalyse Hi Plus if you:
Adults aged 15 years and older should take one 50 mL bottle once daily. Do not exceed the recommended dosage stated on the product label unless advised by a healthcare professional.
Hepalyse Hi Plus can be taken once daily, preferably after a light meal or breakfast. Many people choose to take it during periods of physical fatigue, busy schedules, or after occasions involving alcohol consumption as part of their nutritional support routine.
Yes. Hepalyse Hi Plus may be taken once daily according to the recommended dosage. If you plan to use it for an extended period or have an underlying medical condition, consult your doctor or pharmacist for personalized advice.
Hepalyse Hi Plus is intended for adults aged 15 years and older who experience general fatigue, physical weakness, or who need additional nutritional support during periods of recovery or increased physical demands
Do not use this product if you are under 15 years of age. If you are pregnant, breastfeeding, taking prescription medications, or have an existing medical condition, consult a healthcare professional before use. Avoid taking multiple products containing similar ingredients unless advised by your healthcare provider.
A bright yellow color in the urine may occur because of Vitamin B2 (Riboflavin). This is a normal and harmless effect, as excess vitamin is naturally excreted through the urine.
Zeria Pharmaceutical Co., Ltd. Hepalyse Hi Plus – Official Product Information. Official information on indications, active ingredients, dosage, OTC classification, packaging, and precautions.
Japan Self-Medication Database Center (JSM-DBC). OTC Medicine Search – Hepalyse Hi Plus. Japanese OTC database providing product classification, ingredients, packaging, JAN code, and manufacturer’s suggested retail price (MSRP).
Note: This article is compiled from the official information published by Zeria Pharmaceutical and trusted Japanese pharmaceutical references. It is intended for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment.