

Suitable for individuals experiencing general fatigue who need support for liver function and mild physical recovery. Hepalyse Plus II combines Liver Hydrolysate, Inositol, Vitamin B2, and Vitamin E to help supplement essential nutrients, support liver function, promote metabolism, and improve fatigue and general physical weakness.
Country of Origin: Japan
Brand: Hepalyse (ヘパリーゼ)
Manufacturer: Zeria Pharmaceutical Co., Ltd.
Category: Over-the-Counter (OTC) Medicine – Class 3 Drug
Suggested Retail Price (Japan):
Main benefits:
– Helps relieve general physical fatigue and weakness
– Supports liver, stomach, and intestinal function
– Provides nutritional support during physical exhaustion, illness, or recovery
– Promotes energy metabolism with Inositol, Vitamin B2, and Vitamin E
Directions for use:
– Adults aged 15 years and over
– Take 3 tablets per dose, twice daily
– Total daily dosage: 6 tablets
– Do not use for children under 15 years of age
Liver Hydrolysate is produced by using high-quality natural animal liver that is enzymatically hydrolyzed into small peptides and amino acids.
Instead of requiring the digestive system to break down whole liver proteins, the hydrolysis process converts them into smaller molecules that are more readily absorbed in the small intestine. This helps improve nutrient availability while reducing the digestive workload.
As a result, Liver Hydrolysate provides the body with essential nutrients naturally found in liver, supporting normal liver function, cellular nutrition, and overall metabolism.
The liver is one of the few organs in the human body with a remarkable ability to regenerate. However, this process depends on an adequate supply of amino acids, which serve as the building blocks for cellular repair and protein synthesis.
Liver Hydrolysate naturally contains a broad spectrum of amino acids, including:
In addition, Liver Hydrolysate contains naturally occurring nucleic acid precursors that contribute to normal cellular metabolism.
Supports Liver Cell Regeneration
Liver Hydrolysate provides amino acids and nucleic acid precursors that serve as nutritional building blocks for normal liver cell renewal and maintenance.
Supports Energy Metabolism and Helps Relieve Fatigue
Vitamin B2 helps convert carbohydrates, fats, and proteins into usable energy, while Vitamin E protects cells from oxidative stress. Together, they support normal energy metabolism and help reduce fatigue associated with nutritional deficiency.
Supports Healthy Lipid Metabolism
Inositol contributes to normal lipid metabolism in the liver and supports healthy fat processing, making it a valuable nutrient for individuals seeking to maintain normal liver function and metabolic health.
Hepalyse Plus II may be considered by adults experiencing general fatigue, nutritional deficiency, or physical weakness. People with demanding lifestyles, frequent alcohol consumption, or prolonged stress may also benefit from nutritional support. If you have a diagnosed liver condition, consult your healthcare professional before use.
Yes. As a Class 3 OTC medicine in Japan, Hepalyse Plus II is intended for use according to the recommended dosage. Many adults use it as part of their nutritional support routine, particularly during periods of fatigue or recovery. Follow the instructions on the product label and seek medical advice if symptoms persist.
Hepalyse Plus II is suitable for adults aged 15 years and older who experience general fatigue, physical weakness, nutritional deficiency, or require nutritional support during recovery from illness.
Most people tolerate Hepalyse Plus II well when used as directed. Because it contains Vitamin B2 (Riboflavin), urine may appear bright yellow during use, which is a normal and harmless effect. Discontinue use and consult a healthcare professional if skin rash, itching, or other allergic reactions occur.
No. Hepalyse Plus II is not recommended for individuals under 15 years of age, according to the manufacturer’s instructions.
Store the tablets in a dry place and avoid handling them with wet hands, as moisture may damage the sugar coating. Always use the medicine according to the recommended dosage and discontinue use if any unusual symptoms develop.
Zeria Pharmaceutical Co., Ltd. Hepalyse Plus II – Official Product Information. Official information on indications, active ingredients, dosage, OTC classification, packaging, and precautions.
Japan Self-Medication Database Center (JSM-DBC). OTC Medicine Search – Hepalyse Plus II. Japanese OTC database providing product classification, ingredients, packaging, JAN code, and manufacturer’s suggested retail price (MSRP).
Note: This article is compiled from the official information published by Zeria Pharmaceutical and trusted Japanese pharmaceutical references. It is intended for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment.